DNA damage, p53, apoptosis and vascular disease

John Mercer; Melli Mahmoudi; Martin Bennett

doi:10.1016/j.mrfmmm.2007.02.011

DNA damage, p53, apoptosis and vascular disease

Mutat Res. 2007 Aug 1;621(1-2):75-86. doi: 10.1016/j.mrfmmm.2007.02.011. Epub 2007 Mar 1.

Authors

John Mercer¹, Melli Mahmoudi, Martin Bennett

Affiliation

¹ Division of Cardiovascular Medicine, University of Cambridge, P.O. Box 110, Addenbrooke's Hospital, Cambridge CB2 2QQ, United Kingdom.

PMID: 17382357
DOI: 10.1016/j.mrfmmm.2007.02.011

Abstract

Atherosclerosis is the commonest cause of death in the Western world. The atherosclerotic plaque shows evidence of DNA damage, activation of damage repair pathways, p53 expression and apoptosis, involving a variety of different cell types. This review summarises the evidence for DNA damage in atherosclerosis, the likely stimuli inducing damage, and the increasing role of p53 in mediating apoptosis and its consequences in atherosclerosis.

Publication types

Review

MeSH terms

Animals
Apoptosis* / genetics
Atherosclerosis / genetics
Atherosclerosis / metabolism
Atherosclerosis / pathology
DNA Damage*
Endothelium, Vascular / metabolism
Endothelium, Vascular / pathology
Humans
Oxidative Stress / genetics
Tumor Suppressor Protein p53 / biosynthesis*
Tumor Suppressor Protein p53 / genetics
Vascular Diseases* / genetics
Vascular Diseases* / metabolism
Vascular Diseases* / pathology

Substances

Tumor Suppressor Protein p53