Objective: The FABP2 (intestinal fatty acid-binding protein) gene is expressed in the intestinal epithelial cells and codes for a protein involved in the fatty acid metabolism. We investigated the association of the A54T polymorphism of the FABP2 gene with the metabolic syndrome defined according to the diagnostic criteria recommended by the IDF in 2005, in our region (Marosvásárhely - Tg. Mures, Romania).
Research design and methods: A case-control study was carried out on 144 metabolic syndrome patients and 73 healthy persons with similar age and lifestyle. Insulin resistance was measured by the HOMA and QUICKI indices, and gene polymorphism was analyzed with PCR followed by restriction enzyme digestion with Hha I.
Results: The T54 allele was more frequent in the metabolic syndrome group than in controls (35.71% vs. 28.08%, p < 0.05). In the presence of the T54 allele we have noticed a slight but statistically significant risk, more marked in the case of TT homozygotes (TT vs. AT + AA: OR = 4.31, CI 95% 1.21-5.29, p = 0.015 and TT vs. AA: OR = 4.61, CI95%: 1.24-7.03, p = 0.0195). No significant differences of the followed metabolic parameters were observed between persons having different genotypes in the two study groups.
Conclusions: These results suggest that the FABP2 T54 allele may have a minor contribution to the metabolic syndrome in our region.