A case of interleukin-12 receptor beta-1 deficiency with recurrent leishmaniasis

Pediatr Infect Dis J. 2007 Apr;26(4):366-8. doi: 10.1097/01.inf.0000258696.64507.0f.

Abstract

Interleukin-12 receptor beta-1 (IL-12Rbeta1) defect is generally associated with selective susceptibility to weakly pathogenic mycobacteria and Salmonella species. Patients rarely experience infections caused by other organisms. We report a 5-year-old patient with IL-12Rbeta1 deficiency who developed recurrent visceral leishmaniasis 6 months apart. The patient responded to lyposomal amphotericin B treatment reasonably well.

Publication types

  • Case Reports

MeSH terms

  • Amphotericin B / therapeutic use
  • Anti-Infective Agents / therapeutic use
  • Antiprotozoal Agents / therapeutic use
  • Child, Preschool
  • Ciprofloxacin / therapeutic use
  • Genetic Predisposition to Disease*
  • Humans
  • Leishmaniasis, Visceral / drug therapy
  • Leishmaniasis, Visceral / genetics*
  • Leishmaniasis, Visceral / immunology*
  • Leishmaniasis, Visceral / prevention & control
  • Male
  • Receptors, Interleukin-12 / deficiency*
  • Receptors, Interleukin-12 / genetics
  • Receptors, Interleukin-12 / metabolism
  • Recurrence
  • Salmonella Infections / drug therapy
  • Salmonella Infections / genetics
  • Salmonella Infections / immunology

Substances

  • Anti-Infective Agents
  • Antiprotozoal Agents
  • IL12RB1 protein, human
  • Receptors, Interleukin-12
  • liposomal amphotericin B
  • Ciprofloxacin
  • Amphotericin B