Family-based association study between GRIK2 polymorphisms and autism spectrum disorders in the Korean trios

Neurosci Res. 2007 Jul;58(3):332-5. doi: 10.1016/j.neures.2007.03.002. Epub 2007 Mar 13.

Abstract

Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder with strong genetic components. The present study comprises the detection of four single nucleotide polymorphisms (SNPs) in GRIK2 followed by a family-based association analysis of the SNPs in 126 Korean ASD trios by using the transmission disequilibrium test (TDT) and haplotype analysis. We found preferential transmission of the C allele at the rs3213607 (P<0.001) of GRIK2 in ASD and haplotype analysis revealed that one haplotype demonstrated a significant association (P=0.023). These results suggest a potential association between GRIK2 and ASD in the Korean population.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Autistic Disorder / epidemiology
  • Autistic Disorder / genetics*
  • Child
  • Child, Preschool
  • Family Health*
  • Female
  • Gene Frequency
  • Genotype
  • GluK2 Kainate Receptor
  • Humans
  • Korea / epidemiology
  • Linkage Disequilibrium
  • Male
  • Polymorphism, Single Nucleotide / genetics*
  • Receptors, Kainic Acid / genetics*

Substances

  • Receptors, Kainic Acid