New insights into the combined Cockayne/xeroderma pigmentosum complex: human XPG protein can function in transcription factor stability

Mol Cell. 2007 Apr 27;26(2):162-4. doi: 10.1016/j.molcel.2007.04.002.

Abstract

A new study provides evidence supporting a function for XPG protein in maintaining the integrity and function of TFIIH (Ito et al. [2007], this issue of Molecular Cell). This observation likely explains some of the clinical features of individuals with both defective DNA repair and development.

Publication types

  • Comment
  • Review

MeSH terms

  • Cockayne Syndrome / complications
  • Cockayne Syndrome / genetics*
  • Cockayne Syndrome / metabolism*
  • Cyclin-Dependent Kinase-Activating Kinase
  • Cyclin-Dependent Kinases / metabolism
  • DNA Repair
  • DNA-Binding Proteins / genetics*
  • DNA-Binding Proteins / metabolism*
  • Drug Stability
  • Endonucleases / genetics*
  • Endonucleases / metabolism*
  • Humans
  • Mutation
  • Nuclear Proteins / genetics*
  • Nuclear Proteins / metabolism*
  • Transcription Factor TFIIH / metabolism*
  • Transcription Factors / genetics*
  • Transcription Factors / metabolism*
  • Xeroderma Pigmentosum / complications
  • Xeroderma Pigmentosum / genetics*
  • Xeroderma Pigmentosum / metabolism*

Substances

  • DNA excision repair protein ERCC-5
  • DNA-Binding Proteins
  • Nuclear Proteins
  • Transcription Factors
  • Transcription Factor TFIIH
  • Cyclin-Dependent Kinases
  • Endonucleases
  • Cyclin-Dependent Kinase-Activating Kinase