Abstract
A new study provides evidence supporting a function for XPG protein in maintaining the integrity and function of TFIIH (Ito et al. [2007], this issue of Molecular Cell). This observation likely explains some of the clinical features of individuals with both defective DNA repair and development.
MeSH terms
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Cockayne Syndrome / complications
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Cockayne Syndrome / genetics*
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Cockayne Syndrome / metabolism*
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Cyclin-Dependent Kinase-Activating Kinase
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Cyclin-Dependent Kinases / metabolism
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DNA Repair
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DNA-Binding Proteins / genetics*
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DNA-Binding Proteins / metabolism*
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Drug Stability
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Endonucleases / genetics*
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Endonucleases / metabolism*
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Humans
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Mutation
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Nuclear Proteins / genetics*
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Nuclear Proteins / metabolism*
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Transcription Factor TFIIH / metabolism*
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Transcription Factors / genetics*
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Transcription Factors / metabolism*
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Xeroderma Pigmentosum / complications
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Xeroderma Pigmentosum / genetics*
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Xeroderma Pigmentosum / metabolism*
Substances
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DNA excision repair protein ERCC-5
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DNA-Binding Proteins
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Nuclear Proteins
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Transcription Factors
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Transcription Factor TFIIH
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Cyclin-Dependent Kinases
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Endonucleases
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Cyclin-Dependent Kinase-Activating Kinase