5-lipoxygenase: regulation and possible involvement in atherosclerosis

Olof Rådmark; Bengt Samuelsson

doi:10.1016/j.prostaglandins.2007.01.003

5-lipoxygenase: regulation and possible involvement in atherosclerosis

Prostaglandins Other Lipid Mediat. 2007 May;83(3):162-74. doi: 10.1016/j.prostaglandins.2007.01.003. Epub 2007 Jan 25.

Authors

Olof Rådmark¹, Bengt Samuelsson

Affiliation

¹ Department of Medical Biochemistry and Biophysics, Division of Physiological Chemistry II, Karolinska Institute, S-17177 Stockholm, Sweden. olof.radmark@ki.se

PMID: 17481551
DOI: 10.1016/j.prostaglandins.2007.01.003

Abstract

This review article focuses on two aspects regarding 5-lipoxygenase. First, mechanisms for activation of the enzyme. Second, the involvement of 5-lipoxygenase and leukotrienes in atherosclerosis.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Arachidonate 5-Lipoxygenase / chemistry
Arachidonate 5-Lipoxygenase / genetics
Arachidonate 5-Lipoxygenase / metabolism*
Atherosclerosis / enzymology*
Atherosclerosis / epidemiology
Atherosclerosis / etiology*
Catalysis
Humans
Leukotrienes / metabolism
Lipoxygenase Inhibitors
Models, Biological
Models, Molecular
Nuclear Localization Signals
Phosphorylation
Protein Structure, Tertiary

Substances

Leukotrienes
Lipoxygenase Inhibitors
Nuclear Localization Signals
Arachidonate 5-Lipoxygenase