Abstract
This study was intended to investigate the possible roles of the platelet-derived growth factor (PDGF) gene family's involvement in the pathogenesis of uterine leiomyomata. We examined the differential gene expressions of PDGF-A, -B, -C, -D, PDGF receptor alpha (PDGFR-alpha), and receptor beta (PDGFR-beta) between uterine leiomyomata and the adjacent normal myometrium. Expression of PDGF-C in leiomyomata was significantly higher (approximately 2.4-fold) than in the adjacent normal myometrium, whereas there were no significant differences in the expressions of PDGF-A, -B, -D, PDGFR-alpha, or PDGFR-beta between leiomyomata and the adjacent myometrial tissues.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Female
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Gene Expression Regulation, Neoplastic
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Humans
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Leiomyomatosis / genetics*
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Leiomyomatosis / metabolism
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Lymphokines / genetics*
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Matched-Pair Analysis
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Middle Aged
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Multigene Family
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Myometrium / metabolism
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Platelet-Derived Growth Factor / genetics*
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RNA, Messenger / metabolism
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Receptors, Platelet-Derived Growth Factor / genetics
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Receptors, Platelet-Derived Growth Factor / metabolism
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Up-Regulation
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Uterine Neoplasms / genetics*
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Uterine Neoplasms / metabolism
Substances
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Lymphokines
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Platelet-Derived Growth Factor
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RNA, Messenger
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platelet-derived growth factor C
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Receptors, Platelet-Derived Growth Factor