Association between endometriosis and polymorphisms in endostatin and vascular endothelial growth factor and their serum levels in Korean women

Jung Gu Kim; Ja Yeon Kim; Byung Chul Jee; Chang Suk Suh; Seok Hyun Kim; Young Min Choi

doi:10.1016/j.fertnstert.2007.02.023

Association between endometriosis and polymorphisms in endostatin and vascular endothelial growth factor and their serum levels in Korean women

Fertil Steril. 2008 Jan;89(1):243-5. doi: 10.1016/j.fertnstert.2007.02.023. Epub 2007 May 7.

Authors

Jung Gu Kim¹, Ja Yeon Kim, Byung Chul Jee, Chang Suk Suh, Seok Hyun Kim, Young Min Choi

Affiliation

¹ Department of Obstetrics and Gynecology, College of Medicine, Seoul National University, Seoul, Korea. kimjg@plaza.snu.ac.kr

PMID: 17482599
DOI: 10.1016/j.fertnstert.2007.02.023

Abstract

The aim of present study was to evaluate the relationship between endometriosis and polymorphisms in the endostatin and vascular endothelial growth factor (VEGF) genes, and their levels in serum in a Korean population. Serum endostatin levels (but not VEGF levels) were negatively correlated with the development of endometriosis, specifically in early-stage endometriosis patients, compared with women without endometriosis, but endometriosis was not associated with the endostatin G(4349)A and VEGF C(936)T polymorphisms.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Asian People / genetics*
Case-Control Studies
Endometriosis / blood*
Endometriosis / genetics*
Endostatins / blood*
Endostatins / genetics*
Female
Gene Frequency
Genetic Predisposition to Disease
Humans
Korea
Polymorphism, Single Nucleotide*
Risk Assessment
Risk Factors
Severity of Illness Index
Vascular Endothelial Growth Factor A / blood*
Vascular Endothelial Growth Factor A / genetics*

Substances

Endostatins
VEGFA protein, human
Vascular Endothelial Growth Factor A