Increased MDM2 expression is associated with inferior survival in mantle-cell lymphoma, but not related to the MDM2 SNP309

Haematologica. 2007 Apr;92(4):574-5. doi: 10.3324/haematol.10891.

Abstract

We here show that increased expression of MDM2, a negative regulator of p53, correlates with inferior survival in a series of 43 mantle cell lymphomas. MDM2 overexpression is associated with copy number gains of the MDM2 locus in single tumors, but not with the recently reported MDM2 promoter SNP309.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • DNA Damage
  • DNA Mutational Analysis
  • Female
  • Gene Dosage
  • Gene Duplication
  • Gene Expression Regulation, Neoplastic*
  • Genes, p53
  • Humans
  • Lymphoma, Mantle-Cell / genetics*
  • Lymphoma, Mantle-Cell / metabolism
  • Lymphoma, Mantle-Cell / mortality
  • Male
  • Middle Aged
  • Neoplasm Proteins / biosynthesis*
  • Neoplasm Proteins / genetics
  • Neoplasm Proteins / physiology
  • Polymorphism, Single Nucleotide*
  • Proportional Hazards Models
  • Proto-Oncogene Proteins c-mdm2 / biosynthesis*
  • Proto-Oncogene Proteins c-mdm2 / genetics
  • Proto-Oncogene Proteins c-mdm2 / physiology
  • Reverse Transcriptase Polymerase Chain Reaction
  • Survival Analysis

Substances

  • Neoplasm Proteins
  • MDM2 protein, human
  • Proto-Oncogene Proteins c-mdm2