Abstract
Monocyte chemoattractant protein-1 (MCP-1) is a stimulator of collateral artery growth and has been shown to increase collateral artery conductance in rabbits and pigs. The minimal infusion duration and the minimally effective dose of MCP-1 are currently unknown, as is the sustainability of the therapeutic effect over a longer observation period than tested before. MCP-1 was infused intra-arterially in pigs after unilateral femoral artery occlusion in different doses and infusion durations between 2 hours and 2 weeks. Two weeks after ligation, arterial conductance under maximal vasodilatation was measured. The long-term efficacy was investigated in 2 additional groups of animals after 6 weeks. Infusion with 2 microg/min of MCP-1 for 6 hours was sufficient to double arterial conductance, and arterial conductance after 6 weeks was still significantly increased.
MeSH terms
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Animals
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Arteries / drug effects*
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Arteries / growth & development
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Arteries / physiopathology
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CHO Cells
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Chemokine CCL2 / administration & dosage
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Chemokine CCL2 / genetics
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Chemokine CCL2 / pharmacology*
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Collateral Circulation / drug effects
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Cricetinae
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Cricetulus
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Disease Models, Animal
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Dose-Response Relationship, Drug
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Female
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Femoral Artery / surgery
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Humans
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Infusions, Intra-Arterial
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Ligation / adverse effects
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Male
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Peripheral Vascular Diseases / drug therapy*
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Peripheral Vascular Diseases / etiology
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Peripheral Vascular Diseases / physiopathology
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Receptors, CCR2
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Receptors, Chemokine / genetics
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Receptors, Chemokine / physiology
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Recombinant Proteins / administration & dosage
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Recombinant Proteins / pharmacology
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Swine
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Swine, Miniature
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Time Factors
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Treatment Outcome
Substances
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CCR2 protein, human
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Chemokine CCL2
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Receptors, CCR2
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Receptors, Chemokine
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Recombinant Proteins