Abstract
Although the presence of racial differences in vulvar squamous cell carcinomas has been suggested, fully analyzed data concerning such tumors in Japanese women have not been reported. A total of 21 vulvar squamous cell carcinomas of Japanese women who lived in north-east Japan, were studied with respect to histological subtype, HPV, p53 and p16(INK4a). The majority of tumors consisted of keratinizing and non-keratinizing types (16/21, 76%), all of which were negative for HPV. The remaining five tumors of basaloid, warty or verrucous types were positive for HPV. HPV-negative tumors showed a trend of greater accumulation of gene abnormalities, including p53 gene mutation, than HPV-positive ones. p16(INK4a) overexpression was shown to not always be a marker for vulvar squamous cell carcinoma in Japanese women with activated high-risk HPV.
MeSH terms
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Adult
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Aged
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Aged, 80 and over
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Biomarkers, Tumor / analysis
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Carcinoma, Squamous Cell / chemistry
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Carcinoma, Squamous Cell / epidemiology
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Carcinoma, Squamous Cell / etiology
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Carcinoma, Squamous Cell / pathology*
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Cyclin-Dependent Kinase Inhibitor p16 / analysis
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Cyclin-Dependent Kinase Inhibitor p16 / genetics
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DNA, Neoplasm / analysis
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DNA, Viral / analysis
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Female
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Humans
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Immunoenzyme Techniques
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Japan / epidemiology
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Loss of Heterozygosity
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Middle Aged
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Papillomaviridae / genetics
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Papillomaviridae / isolation & purification
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Papillomavirus Infections / complications
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Papillomavirus Infections / epidemiology
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Papillomavirus Infections / pathology*
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Tumor Suppressor Protein p53 / analysis
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Tumor Suppressor Protein p53 / genetics
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Vulvar Neoplasms / chemistry
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Vulvar Neoplasms / epidemiology
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Vulvar Neoplasms / etiology
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Vulvar Neoplasms / pathology*
Substances
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Biomarkers, Tumor
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Cyclin-Dependent Kinase Inhibitor p16
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DNA, Neoplasm
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DNA, Viral
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Tumor Suppressor Protein p53