Chronic lymphocytic leukemia: keeping cell death at bay

Cell. 2007 Jun 1;129(5):853-5. doi: 10.1016/j.cell.2007.05.023.

Abstract

Chronic lymphocytic leukemia (CLL) is a common adult leukemia caused by abnormal accumulation of B cells. Raval et al. (2007) now implicate dowregulation of the expression of the kinase DAPK1 both genetically and epigenetically in familial and sporadic CLL.

Publication types

  • Comment

MeSH terms

  • Animals
  • Apoptosis
  • Apoptosis Regulatory Proteins / genetics*
  • B-Lymphocytes / cytology
  • Calcium-Calmodulin-Dependent Protein Kinases / genetics*
  • Death-Associated Protein Kinases
  • Epigenesis, Genetic
  • Humans
  • Leukemia, Lymphocytic, Chronic, B-Cell / drug therapy
  • Leukemia, Lymphocytic, Chronic, B-Cell / genetics*
  • Mice

Substances

  • Apoptosis Regulatory Proteins
  • DAPK1 protein, human
  • Dapk1 protein, mouse
  • Death-Associated Protein Kinases
  • Calcium-Calmodulin-Dependent Protein Kinases