Abstract
Chronic lymphocytic leukemia (CLL) is a common adult leukemia caused by abnormal accumulation of B cells. Raval et al. (2007) now implicate dowregulation of the expression of the kinase DAPK1 both genetically and epigenetically in familial and sporadic CLL.
MeSH terms
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Animals
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Apoptosis
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Apoptosis Regulatory Proteins / genetics*
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B-Lymphocytes / cytology
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Calcium-Calmodulin-Dependent Protein Kinases / genetics*
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Death-Associated Protein Kinases
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Epigenesis, Genetic
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Humans
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Leukemia, Lymphocytic, Chronic, B-Cell / drug therapy
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Leukemia, Lymphocytic, Chronic, B-Cell / genetics*
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Mice
Substances
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Apoptosis Regulatory Proteins
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DAPK1 protein, human
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Dapk1 protein, mouse
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Death-Associated Protein Kinases
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Calcium-Calmodulin-Dependent Protein Kinases