Abstract
Eosinophils are pleiotropic multi-functional leukocytes involved in initiation and propagation of diverse inflammatory responses. Recent studies examining eosinophil biology have focused on delineating the molecular basis of FIP1L1/PDGRFalpha-fusion gene induced HES, the molecular steps involved in eosinophil recruitment in tumor-associated eosinophilia and EGID, and the role of eosinophils in asthma. In this review, these studies are summarized, focusing on the implications of these findings in the understanding the role of eosinophils in diseases.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Animals
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Antigen Presentation
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Asthma / immunology
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Asthma / physiopathology
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Chemokine CCL11
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Chemokines, CC / physiology
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Chemotaxis, Leukocyte / physiology
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Cytokines / metabolism
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Cytokines / physiology
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Disease Models, Animal
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Eosinophil Granule Proteins / physiology
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Eosinophilia / etiology
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Eosinophils / immunology
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Eosinophils / physiology*
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Humans
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Hypereosinophilic Syndrome / genetics
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Hypereosinophilic Syndrome / physiopathology
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Inflammation / blood
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Inflammation / etiology
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Inflammation / immunology
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Inflammation Mediators / physiology
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Intestinal Diseases, Parasitic / immunology
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Intestinal Diseases, Parasitic / pathology
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Leukemia, Myelogenous, Chronic, BCR-ABL Positive / blood
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Leukemia, Myelogenous, Chronic, BCR-ABL Positive / complications
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Mice
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Mice, Knockout
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Mice, Transgenic
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Neoplasms / blood
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Neoplasms / complications
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Oncogene Proteins, Fusion / physiology
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Radiation Chimera
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Receptor, Platelet-Derived Growth Factor alpha / physiology
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mRNA Cleavage and Polyadenylation Factors / physiology
Substances
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CCL11 protein, human
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Ccl11 protein, mouse
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Chemokine CCL11
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Chemokines, CC
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Cytokines
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Eosinophil Granule Proteins
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Inflammation Mediators
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Oncogene Proteins, Fusion
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mRNA Cleavage and Polyadenylation Factors
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FIP1L1-PDGFRA fusion protein, human
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Receptor, Platelet-Derived Growth Factor alpha