Abstract
Toll-like receptor 4 (TLR4) plays an important role in the pattern recognition of Mycobacterium tuberculosis, and polymorphisms in the TLR4 gene influence the function of the receptor. We therefore investigated in a cohort of HIV-infected Tanzanian patients whether the Asp299Gly TLR4 polymorphism is associated with the development of active tuberculosis. We found a greater risk of developing active tuberculosis as well as a reduction in CD4 T-cell counts in patients with the Asp299Gly TLR4 polymorphism.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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CD4 Lymphocyte Count
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Cohort Studies
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Gene Frequency
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Genetic Predisposition to Disease / genetics
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HIV Infections / complications
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HIV Infections / epidemiology
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HIV Infections / genetics*
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Humans
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Polymorphism, Genetic / genetics*
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Tanzania / epidemiology
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Toll-Like Receptor 4 / genetics*
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Tuberculosis, Pulmonary / complications
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Tuberculosis, Pulmonary / epidemiology
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Tuberculosis, Pulmonary / genetics*
Substances
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TLR4 protein, human
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Toll-Like Receptor 4