Preliminary analysis of the G178A polymorphism of insulin-like factor 3 in male infertility

Yeo-Jin Yun; Han-Chul Lee; Jee-Eun Kim; Seung-Hun Song; Suman Lee

doi:10.1016/j.fertnstert.2007.01.107

Preliminary analysis of the G178A polymorphism of insulin-like factor 3 in male infertility

Fertil Steril. 2007 Dec;88(6):1706-8. doi: 10.1016/j.fertnstert.2007.01.107. Epub 2007 Jun 7.

Authors

Yeo-Jin Yun¹, Han-Chul Lee, Jee-Eun Kim, Seung-Hun Song, Suman Lee

Affiliation

¹ Functional Genomics Lab, CHA Research Institute, Bundang Campus, College of Medicine, Pochon CHA University, Sungnam City, Kyunggi-Do, Korea.

PMID: 17559848
DOI: 10.1016/j.fertnstert.2007.01.107

Abstract

We investigated the association of nonsynonymous insulin-like factor 3 (INSL3) G178A polymorphism with nonobstructive male infertility. The common INSL3 G178A polymorphism was not statistically significantly associated with male infertility (P>.05), even though INSL3 is essential for the occurrence of bilateral cryptorchidism.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alleles
Case-Control Studies
DNA Mutational Analysis
Genetic Linkage
Genetic Testing
Humans
Infertility, Male / genetics*
Insulin / genetics*
Male
Polymorphism, Single Nucleotide*
Proteins / genetics*

Substances

Insulin
Leydig insulin-like protein
Proteins