Fine mapping of a human chromosome 6 ferritin heavy chain pseudogene: relevance to haemochromatosis

Hum Genet. 1991 Dec;88(2):175-8. doi: 10.1007/BF00206067.

Abstract

We have used a somatic cell hybrid regional mapping panel for the short arm of chromosome 6, linkage analysis and a population study to map in detail a previously described ferritin heavy chain pseudogene sequence on chromosome 6. Our results show that this sequence maps to the short arm of chromosome 6 centromeric to the glyoxylase locus. The ferritin pseudogene locus is thus distant from the locus for the iron storage disease haemochromatosis, confirming previous evidence that this sequence is not a candidate for the haemochromatosis gene.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Chromosome Mapping
  • Chromosomes, Human, Pair 6*
  • DNA Probes / genetics
  • Ferritins / genetics*
  • Genetic Linkage / genetics*
  • HLA-B Antigens / genetics
  • Hemochromatosis / genetics*
  • Humans
  • Hybrid Cells
  • Pseudogenes / genetics*

Substances

  • DNA Probes
  • HLA-B Antigens
  • Ferritins