Abstract
Cerebral veno-sinus thrombosis (CVT) during puerperium may have fatal consequences. A nonspecific clinical picture must be complete with computed tomography of the brain and digital substract angiography of the brain blood vessels, and, once the clinical diagnosis is confirmed, coagulation tests and genetic analysis of the coagulation factor are to be made as well. Genetic polymorphisms associated with thrombophilia such as factor V Leiden, prothrombin G20210A, MTHFR C677T, ACE and PIA1/A2 may be the cause of the hypercoagulability that results in CVT.
MeSH terms
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Adult
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Blood Coagulation / genetics*
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Factor V / genetics
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Female
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Genetic Predisposition to Disease
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Humans
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Methylenetetrahydrofolate Reductase (NADPH2) / genetics
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Mutation*
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Peptidyl-Dipeptidase A / genetics
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Plasminogen Activator Inhibitor 1 / genetics
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Plasminogen Activator Inhibitor 2 / genetics
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Postpartum Period*
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Pregnancy
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Pregnancy Complications, Cardiovascular / blood
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Pregnancy Complications, Cardiovascular / genetics*
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Pregnancy Complications, Cardiovascular / pathology
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Prothrombin / genetics
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Sagittal Sinus Thrombosis / blood
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Sagittal Sinus Thrombosis / genetics*
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Sagittal Sinus Thrombosis / pathology
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Thrombophilia / blood
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Thrombophilia / complications
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Thrombophilia / genetics*
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Thrombophilia / pathology
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Tomography, X-Ray Computed
Substances
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Plasminogen Activator Inhibitor 1
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Plasminogen Activator Inhibitor 2
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SERPINE1 protein, human
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factor V Leiden
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Factor V
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Prothrombin
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Methylenetetrahydrofolate Reductase (NADPH2)
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Peptidyl-Dipeptidase A