Functional activity of 5-HT4 receptors in children with congenital heart disease

Bull Exp Biol Med. 2006 Dec;142(6):717-9. doi: 10.1007/s10517-006-0460-1.
[Article in English, Russian]

Abstract

The effect of 5-methoxytryptamine (5-HT(4) receptor agonist) on the inotropic function of atrial myocardium was studied in children aged 2 months to 17 years, operated on for congenital heart disease. Functional activity of 5-HT(4) receptors was 8.4 times higher in dysfunction of the atrial septum in comparison with other congenital heart diseases. The positive inotropic effects of 5-HT(4) receptor agonist can promote compensation of myocardial work in children with pathological circulation.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • 5-Methoxytryptamine / pharmacology
  • Adolescent
  • Child
  • Child, Preschool
  • Dose-Response Relationship, Drug
  • Heart Atria / drug effects
  • Heart Atria / metabolism
  • Heart Atria / surgery
  • Heart Defects, Congenital / complications*
  • Heart Defects, Congenital / surgery
  • Heart Septal Defects, Atrial / complications
  • Heart Septal Defects, Atrial / surgery
  • Humans
  • Infant
  • Myocardium / metabolism
  • Receptors, Serotonin, 5-HT4 / metabolism*
  • Serotonin 5-HT4 Receptor Agonists

Substances

  • Serotonin 5-HT4 Receptor Agonists
  • Receptors, Serotonin, 5-HT4
  • 5-Methoxytryptamine