Functional activity of 5-HT4 receptors in children with congenital heart disease
Bull Exp Biol Med. 2006 Dec;142(6):717-9.
doi: 10.1007/s10517-006-0460-1.
[Article in
English,
Russian]
Affiliation
- 1 Kazan State Medical University, Kazan, Russia. mustafinnn@mail.ru
Abstract
The effect of 5-methoxytryptamine (5-HT(4) receptor agonist) on the inotropic function of atrial myocardium was studied in children aged 2 months to 17 years, operated on for congenital heart disease. Functional activity of 5-HT(4) receptors was 8.4 times higher in dysfunction of the atrial septum in comparison with other congenital heart diseases. The positive inotropic effects of 5-HT(4) receptor agonist can promote compensation of myocardial work in children with pathological circulation.
Publication types
-
Comparative Study
-
Research Support, Non-U.S. Gov't
MeSH terms
-
5-Methoxytryptamine / pharmacology
-
Adolescent
-
Child
-
Child, Preschool
-
Dose-Response Relationship, Drug
-
Heart Atria / drug effects
-
Heart Atria / metabolism
-
Heart Atria / surgery
-
Heart Defects, Congenital / complications*
-
Heart Defects, Congenital / surgery
-
Heart Septal Defects, Atrial / complications
-
Heart Septal Defects, Atrial / surgery
-
Humans
-
Infant
-
Myocardium / metabolism
-
Receptors, Serotonin, 5-HT4 / metabolism*
-
Serotonin 5-HT4 Receptor Agonists
Substances
-
Serotonin 5-HT4 Receptor Agonists
-
Receptors, Serotonin, 5-HT4
-
5-Methoxytryptamine