The X factor: skewing X inactivation towards cancer

René H Medema; Boudewijn M Th Burgering

doi:10.1016/j.cell.2007.06.008

The X factor: skewing X inactivation towards cancer

Cell. 2007 Jun 29;129(7):1253-4. doi: 10.1016/j.cell.2007.06.008.

Authors

René H Medema¹, Boudewijn M Th Burgering

Affiliation

¹ Department of Medical Oncology, University Medical Center Utrecht, Universiteitsweg 100, Stratenum, 3584CG Utrecht, The Netherlands. r.h.medema@umcutrecht.nl

PMID: 17604714
DOI: 10.1016/j.cell.2007.06.008

Abstract

Increased expression of the epidermal growth factor receptor HER-2/ErbB2 is frequently observed in breast cancer and is targeted by the anticancer drug Herceptin. Now, Zuo et al. (2007) reveal that an X-linked gene encoding the transcription factor FOXP3 is a breast cancer tumor suppressor that represses expression of HER2/ErbB2.

Publication types

Comment
Review

MeSH terms

Animals
Breast Neoplasms / genetics
Cell Transformation, Neoplastic / genetics*
Chromosomes, Human, X / genetics*
Forkhead Transcription Factors / genetics*
Gene Expression Regulation, Neoplastic / genetics
Humans
Mutation / genetics
Receptor, ErbB-2 / genetics*
Tumor Suppressor Proteins / genetics*
X Chromosome Inactivation / genetics*

Substances

FOXP3 protein, human
Forkhead Transcription Factors
Tumor Suppressor Proteins
Receptor, ErbB-2