Abstract
NADH dehydrogenase (complex I) couples the oxidation of NADH for the reduction of ubiquinone with the generation of a proton gradient that can be used for the synthesis of ATP. We have found a missense mutation in the MT-ND5 subunit of NADH dehydrogenase in the Tibet chicken breed. In the present study, the mitochondrial respiratory control ratio (RCR) and NADH dehydrogenase activity in Tibet chicken embryonic brain with different genotypes were measured. Significant differences between animals carrying mitochondria with the EF493865.1:m.1627A vs. EF493865.1:m.1627C alleles were observed for RCR and enzyme activity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Base Sequence
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Cell Hypoxia / genetics
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Chick Embryo
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Electron Transport Complex I / genetics*
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Electron Transport Complex I / metabolism
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Female
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Genetic Variation*
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Mitochondria / enzymology*
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Mitochondria / genetics*
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Mitochondrial Proteins / genetics*
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Mitochondrial Proteins / metabolism
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Molecular Sequence Data
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NADH Dehydrogenase / genetics*
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NADH Dehydrogenase / metabolism*
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NADH Dehydrogenase / physiology
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Protein Subunits / genetics
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Protein Subunits / metabolism
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Tibet
Substances
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Mitochondrial Proteins
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Protein Subunits
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NADH Dehydrogenase
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Electron Transport Complex I