Abstract
Exploring the role of junctional adhesion molecules (JAMs) has proven to be varied and controversial. The purpose of this review is to discuss the new and exciting roles of these IgSF molecules and how they have evolved to contribute to diverse functions from development to inflammation. In particular, recent research has focused on JAM subfamily members JAM-A, -B, and -C with newly described roles in leukocyte trafficking during inflammation and angiogenesis. However, research on all JAM family members has demonstrated recurring themes with striking similarities in the many diverse processes they are now known to regulate.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Amino Acid Sequence
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Animals
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Cell Adhesion Molecules / chemistry
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Cell Adhesion Molecules / immunology
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Cell Adhesion Molecules / metabolism*
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Endothelial Cells / immunology
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Endothelial Cells / metabolism*
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Humans
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Inflammation / metabolism
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Junctional Adhesion Molecules
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Leukocyte Rolling* / immunology
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Leukocytes / immunology
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Leukocytes / metabolism*
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Ligands
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Molecular Sequence Data
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Multiprotein Complexes / metabolism
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Protein Isoforms / metabolism
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Protein Structure, Tertiary
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Signal Transduction* / immunology
Substances
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Cell Adhesion Molecules
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Junctional Adhesion Molecules
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Ligands
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Multiprotein Complexes
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Protein Isoforms