Association study of the paraoxonase 1 gene with the risk of developing Alzheimer's disease

Julien Chapuis; Maud Boscher; Faiza Bensemain; Dominique Cottel; Philippe Amouyel; Jean-Charles Lambert

doi:10.1016/j.neurobiolaging.2007.05.021

Association study of the paraoxonase 1 gene with the risk of developing Alzheimer's disease

Neurobiol Aging. 2009 Jan;30(1):152-6. doi: 10.1016/j.neurobiolaging.2007.05.021. Epub 2007 Jul 12.

Authors

Julien Chapuis¹, Maud Boscher, Faiza Bensemain, Dominique Cottel, Philippe Amouyel, Jean-Charles Lambert

Affiliation

¹ INSERM U744, Institut Pasteur de Lille, Université de Lille 2, Lille, France.

PMID: 17624629
DOI: 10.1016/j.neurobiolaging.2007.05.021

Abstract

Recently, a region encompassing the promoter and intron 1 of the paraoxonase 1 gene (PON1) have been associated with the risk of developing Alzheimer's disease (AD) in a large pan-ethnic (Caucasian and African-American) dataset. We attempted to replicate this observation in a large French study of sporadic cases and controls. We confirmed that the proximal promoter and 5' sequence of the PON1 gene may harbor unknown functional variant(s) associated with the risk of developing AD.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged
Alzheimer Disease / epidemiology*
Alzheimer Disease / genetics*
Aryldialkylphosphatase / genetics*
Female
France / epidemiology
Genetic Predisposition to Disease / epidemiology
Genetic Predisposition to Disease / genetics
Humans
Male
Polymorphism, Single Nucleotide / genetics*
Prevalence
Risk Assessment / methods*
Risk Factors

Substances

Aryldialkylphosphatase
PON1 protein, human