Association of the DAO and DAOA gene polymorphisms with autism spectrum disorders in boys in Korea: a preliminary study

Seockhoon Chung; Jin Pyo Hong; Hanik K Yoo

doi:10.1016/j.psychres.2007.02.007

Association of the DAO and DAOA gene polymorphisms with autism spectrum disorders in boys in Korea: a preliminary study

Psychiatry Res. 2007 Oct 31;153(2):179-82. doi: 10.1016/j.psychres.2007.02.007. Epub 2007 Jul 16.

Authors

Seockhoon Chung¹, Jin Pyo Hong, Hanik K Yoo

Affiliation

¹ Department of Psychiatry, University of Ulsan College of Medicine, Asan Medical Center, 388-1 Pungnap-2dong, Songpa-gu, Seoul 138-736, Republic of Korea.

PMID: 17629951
DOI: 10.1016/j.psychres.2007.02.007

Abstract

We examined the association of autism spectrum disorders (ASD) with polymorphisms in the DAO and DAOA genes. The sample comprised 57 children with ASD, 47 complete trios, and 83 healthy controls in Korea. Although the transmission disequilibrium test showed no association, a population-based case-control study showed significant associations between the rs3918346 and rs3825251 SNPs of the DAO gene and boys with ASD.

MeSH terms

Autistic Disorder / ethnology*
Autistic Disorder / genetics*
Autistic Disorder / metabolism
Carrier Proteins / genetics*
Child, Preschool
Diagnostic and Statistical Manual of Mental Disorders
Humans
Intracellular Signaling Peptides and Proteins
Korea / epidemiology
Male
Polymorphism, Genetic / genetics*
Prevalence
Receptors, AMPA / metabolism

Substances

Carrier Proteins
DAOA protein, human
Intracellular Signaling Peptides and Proteins
Receptors, AMPA