SAP discovery: the sword edges--beneficial and harmful

Shigemasa Sawada; Masami Takei; Tetsuyosi Ishiwata

doi:10.1016/j.autrev.2007.01.015

SAP discovery: the sword edges--beneficial and harmful

Autoimmun Rev. 2007 Aug;6(7):444-9. doi: 10.1016/j.autrev.2007.01.015. Epub 2007 Feb 23.

Authors

Shigemasa Sawada¹, Masami Takei, Tetsuyosi Ishiwata

Affiliation

¹ Department of Rheumatology and Hematology, Nihon University Nerima Hikarigaoka Hospital, Tokyo, Japan. sswd98@med.nihon-u.ac.jp

PMID: 17643931
DOI: 10.1016/j.autrev.2007.01.015

Abstract

We cloned the SLAM associated protein (SAP) gene in 1995. In 1998, it was discovered that the SAP gene was defective in patients with X-linked lymphoproliferative disease. Subsequently, details on the key role of life-long immune memory (vaccination) and of life-long autoantibody production in patients suffering from autoimmune disease have been revealed. In this paper, we discuss the dual nature of SAP in humans: its beneficial effect on life-long immune memory (vaccination) and its harmful effect on life-long autoantibody production.

Publication types

Review

MeSH terms

Arthritis, Rheumatoid / immunology*
Arthritis, Rheumatoid / physiopathology
Autoantibodies / blood
Epstein-Barr Virus Infections / immunology*
Humans
Immunologic Memory
Intracellular Signaling Peptides and Proteins / genetics
Intracellular Signaling Peptides and Proteins / immunology*
Intracellular Signaling Peptides and Proteins / physiology
Signaling Lymphocytic Activation Molecule Associated Protein
Synovitis / immunology*
Synovitis / physiopathology

Substances

Autoantibodies
Intracellular Signaling Peptides and Proteins
SH2D1A protein, human
Signaling Lymphocytic Activation Molecule Associated Protein