Abstract
Quinone oxidoreductase (NQO1) plays a key role in the cellular antioxidant defense by detoxifying quinine derivatives. Case-control association study of the possible relationship between the NQO1 gene polymorphism and mood disorders (patients with major depressive disorder, n=61; patients with bipolar I disorder, n=80; control, n=106) was carried out using PCR-based techniques. These preliminary results showed that the NQO1 gene polymorphism was not related to a susceptibility to mood disorders.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Bipolar Disorder / diagnosis
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Bipolar Disorder / genetics*
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Bipolar Disorder / psychology
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Depressive Disorder, Major / diagnosis
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Depressive Disorder, Major / genetics*
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Depressive Disorder, Major / psychology
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Female
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Genetic Predisposition to Disease / genetics*
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Genotype
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Humans
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Korea
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Male
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Middle Aged
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NAD(P)H Dehydrogenase (Quinone) / genetics*
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Polymorphism, Genetic / genetics*
Substances
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NAD(P)H Dehydrogenase (Quinone)
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NQO1 protein, human