Vitamin D receptor: a highly versatile nuclear receptor

Kidney Int. 2007 Aug;72(3):237-9. doi: 10.1038/sj.ki.5002428.

Abstract

Vitamin D receptor (VDR) modulators are used to treat hyperparathyroidism secondary to chronic kidney disease (CKD). The therapy is associated with reduced mortality in stage 5 CKD patients, who experience an extremely high cardiovascular disease (CVD)-related mortality rate. Chen et al. report that VDR is involved in regulating type A natriuretic peptide receptor (NPR-A) in inner medullary collecting duct cells. The regulation of NPR-A may be one of several mechanisms by which VDR activation reduces CVD risk in CKD.

Publication types

  • Comment

MeSH terms

  • 25-Hydroxyvitamin D3 1-alpha-Hydroxylase / metabolism
  • Animals
  • Cardiovascular Diseases / etiology
  • Cardiovascular Diseases / physiopathology
  • Chronic Disease
  • Guanylate Cyclase / metabolism*
  • Humans
  • Kidney Diseases / complications
  • Kidney Diseases / physiopathology
  • Mice
  • Mice, Knockout
  • Rats
  • Receptors, Atrial Natriuretic Factor / metabolism*
  • Receptors, Calcitriol / genetics
  • Receptors, Calcitriol / physiology*
  • Receptors, Cytoplasmic and Nuclear / physiology*

Substances

  • Receptors, Calcitriol
  • Receptors, Cytoplasmic and Nuclear
  • 25-Hydroxyvitamin D3 1-alpha-Hydroxylase
  • Guanylate Cyclase
  • Receptors, Atrial Natriuretic Factor
  • atrial natriuretic factor receptor A