Abstract
This article describes the remarkable progress that has been made over the past decade in identifying the genetic contribution to frontotemporal dementia. The clinical and neuropathologic features of frontotemporal dementia with parkinsonism linked to chromosome 17 and the nature of the mutations in the progranulin and microtubule-associated protein tau genes are emphasized.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Adenosine Triphosphatases / genetics
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Animals
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Cell Cycle Proteins / genetics
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Dementia / genetics*
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Dementia / pathology
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Endosomal Sorting Complexes Required for Transport
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Frontal Lobe / pathology
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Humans
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Intercellular Signaling Peptides and Proteins / genetics
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Nerve Tissue Proteins / genetics
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Progranulins
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Temporal Lobe / pathology
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Valosin Containing Protein
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tau Proteins / genetics
Substances
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CHMP2B protein, human
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Cell Cycle Proteins
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Endosomal Sorting Complexes Required for Transport
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GRN protein, human
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Intercellular Signaling Peptides and Proteins
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MAPT protein, human
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Nerve Tissue Proteins
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Progranulins
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tau Proteins
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Adenosine Triphosphatases
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Valosin Containing Protein