PIK3CA gene amplification in Japanese non-small cell lung cancer

Osamu Kawano; Hidefumi Sasaki; Katsuhiro Okuda; Haruhiro Yukiue; Tomoki Yokoyama; Motoki Yano; Yoshitaka Fujii

doi:10.1016/j.lungcan.2007.06.020

PIK3CA gene amplification in Japanese non-small cell lung cancer

Lung Cancer. 2007 Oct;58(1):159-60. doi: 10.1016/j.lungcan.2007.06.020. Epub 2007 Aug 6.

Authors

Osamu Kawano, Hidefumi Sasaki, Katsuhiro Okuda, Haruhiro Yukiue, Tomoki Yokoyama, Motoki Yano, Yoshitaka Fujii

PMID: 17681398
DOI: 10.1016/j.lungcan.2007.06.020

Abstract

We have investigated 92 non-small cell lung cancer tissues and found 11 PIK3CA amplification. PIK3CA amplification incidence was significantly higher in male, smoker and squamous cell carcinoma patients. Among 11 patients with PIK3CA amplification, two patients harbored a PIK3CA mutation. There was significant difference in survival between the patients with PIK3CA normal copy number and the patients with PIK3CA amplification.

Publication types

Letter

MeSH terms

Carcinoma, Non-Small-Cell Lung / genetics*
Carcinoma, Non-Small-Cell Lung / mortality
Carcinoma, Squamous Cell / genetics*
Carcinoma, Squamous Cell / mortality
Class I Phosphatidylinositol 3-Kinases
Female
Gene Amplification*
Genetic Markers
Humans
Lung Neoplasms / genetics*
Lung Neoplasms / mortality
Male
Phosphatidylinositol 3-Kinases / genetics*
Sex Factors
Smoking
Survival Analysis

Substances

Genetic Markers
Phosphatidylinositol 3-Kinases
Class I Phosphatidylinositol 3-Kinases
PIK3CA protein, human