Abstract
Calsequestrin 1 (CASQ1) is a calcium storage protein of fast-twitch skeletal muscle cells. In previous human association studies the results have been contradictory regarding the association between a CASQ1 rs2275703 polymorphism and type 2 diabetes. In the present study of the CASQ1 rs2275703 polymorphism in 7,088 Danish whites the allele frequency and genotype distribution did not differ between type 2 diabetic patients and glucose-tolerant control subjects, neither was found any association with diabetes-related quantitative traits.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Blood Glucose / metabolism
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Calcium-Binding Proteins / genetics*
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Calsequestrin
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Case-Control Studies
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Denmark / epidemiology
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Diabetes Mellitus, Type 2 / epidemiology
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Diabetes Mellitus, Type 2 / genetics*
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Dyslipidemias / epidemiology
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Dyslipidemias / genetics*
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Ethnicity
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Female
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Gene Frequency
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Genotype
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Glucose Tolerance Test
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Humans
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Insulin / metabolism
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Male
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Middle Aged
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Mitochondrial Proteins / genetics*
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Obesity / epidemiology
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Obesity / genetics*
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Polymorphism, Single Nucleotide / genetics*
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White People
Substances
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Blood Glucose
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CASQ1 protein, human
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Calcium-Binding Proteins
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Calsequestrin
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Insulin
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Mitochondrial Proteins