HLA-G expression in malignant melanoma

Vera Rebmann; Stefan Wagner; Hans Grosse-Wilde

doi:10.1016/j.semcancer.2007.06.010

HLA-G expression in malignant melanoma

Semin Cancer Biol. 2007 Dec;17(6):422-9. doi: 10.1016/j.semcancer.2007.06.010. Epub 2007 Jun 28.

Authors

Vera Rebmann¹, Stefan Wagner, Hans Grosse-Wilde

Affiliation

¹ Institut für Immunologie, Universitätsklinikum Essen, Virchowstr. 171, D-45122 Essen, Germany. immunologie@uni-essen.de

PMID: 17689098
DOI: 10.1016/j.semcancer.2007.06.010

Abstract

Both, the expression of HLA-G (a non-classical HLA class I molecule) and the loss of classical HLA class I molecules enable tumor cells to evade from immunosurveillance of the host. Whereas HLA-G down-modulates the immune functions of all cells participating in the immune defence mechanisms, defects on HLA class I expression result in the resistance of tumor cells to cytotoxic T lymphocytes attacks. This contribution reviews the HLA-G expression pattern in malignant melanoma lesions, its correlation to the loss of classical HLA class I antigens, and new aspects of HLA-G regulation.

Publication types

Review

MeSH terms

Cell Line, Tumor
Gene Expression Regulation, Neoplastic
HLA Antigens / chemistry
HLA Antigens / genetics
HLA Antigens / immunology
HLA Antigens / metabolism*
HLA-G Antigens
Histocompatibility Antigens Class I / chemistry
Histocompatibility Antigens Class I / genetics
Histocompatibility Antigens Class I / immunology
Histocompatibility Antigens Class I / metabolism*
Humans
Immunologic Surveillance
Melanoma / genetics
Melanoma / immunology*
Melanoma / metabolism
Skin Neoplasms / genetics
Skin Neoplasms / immunology*
Skin Neoplasms / metabolism
Tumor Escape

Substances

HLA Antigens
HLA-G Antigens
Histocompatibility Antigens Class I