Abstract
We report a false negative histochemical reaction for myophosphorylase in the case of an 11 year old with fulminant Staphylococcus aureus. Due to increased creatine kinase levels and marked myoglobinuria a muscle biopsy was performed prior to death. The biopsy revealed rhabdomyolysis, glycogen depletion and absent myophosphorylase reactivity. Subsequent myophosphorylase quantification was normal. This unique case of a false negative myophosphorylase histochemical reaction is apparently related to sepsis.
MeSH terms
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Autopsy
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Biomarkers / analysis
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Biomarkers / metabolism
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Child
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Creatine Kinase / analysis
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Creatine Kinase / blood
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Diagnosis, Differential
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False Negative Reactions
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Fatal Outcome
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Glycogen / deficiency
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Glycogen Phosphorylase, Muscle Form / analysis
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Glycogen Phosphorylase, Muscle Form / metabolism*
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Histocytochemistry
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Humans
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Male
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Methicillin Resistance
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Muscle, Skeletal / enzymology*
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Muscle, Skeletal / pathology
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Muscle, Skeletal / physiopathology
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Myocardium / enzymology
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Myocardium / pathology
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Rhabdomyolysis / diagnosis*
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Rhabdomyolysis / enzymology*
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Rhabdomyolysis / microbiology
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Sepsis / complications*
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Sepsis / physiopathology
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Staphylococcal Infections / complications*
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Staphylococcal Infections / physiopathology
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Staphylococcus aureus
Substances
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Biomarkers
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Glycogen
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Glycogen Phosphorylase, Muscle Form
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Creatine Kinase