Abstract
There is growing evidence that herpes simplex virus type 1 (HSV-1), together with the apolipoprotein E 4 (APOE4) allele, contribute to the pathogenesis of Alzheimer's disease (AD), although the mechanism of their interaction remains uncertain. Here we show that the combination of inherited APOE genotype and vertical transmission of HSV-1 confers a differential risk of brain infection. These risk factors are known to be associated with AD.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alzheimer Disease / etiology*
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Alzheimer Disease / genetics
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Alzheimer Disease / virology
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Animals
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Apolipoproteins E / genetics*
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Brain / virology*
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DNA, Viral / analysis
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DNA, Viral / blood
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Genetic Predisposition to Disease*
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Herpes Simplex / complications*
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Herpes Simplex / transmission
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Herpesvirus 1, Human / isolation & purification*
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Humans
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Infectious Disease Transmission, Vertical*
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Mice
Substances
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Apolipoproteins E
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DNA, Viral