NPM1 mutations are more stable than FLT3 mutations during the course of disease in patients with acute myeloid leukemia

Michela Palmisano; Tiziana Grafone; Emanuela Ottaviani; Nicoletta Testoni; Michele Baccarani; Giovanni Martinelli

doi:10.3324/haematol.11202

NPM1 mutations are more stable than FLT3 mutations during the course of disease in patients with acute myeloid leukemia

Haematologica. 2007 Sep;92(9):1268-9. doi: 10.3324/haematol.11202.

Authors

Michela Palmisano, Tiziana Grafone, Emanuela Ottaviani, Nicoletta Testoni, Michele Baccarani, Giovanni Martinelli

PMID: 17768124
DOI: 10.3324/haematol.11202

Abstract

NPM1 mutations have been reported to be the most frequent mutations in acute myeloid leukemia (AML). They are associated with a wide spectrum of morphologic subtypes of AML, normal karyotype and FLT3 mutations. The high frequency of NPM1 mutations might provide a suitable marker for monitoring residual disease of AML.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Acute Disease
DNA Mutational Analysis
Disease Progression
Humans
Leukemia, Myeloid / genetics*
Mutation / genetics*
Neoplasm, Residual / diagnosis
Neoplasm, Residual / genetics*
Nuclear Proteins / genetics*
Nucleophosmin
Phosphoproteins / genetics
fms-Like Tyrosine Kinase 3 / genetics*

Substances

NPM1 protein, human
Nuclear Proteins
Phosphoproteins
Nucleophosmin
FLT3 protein, human
fms-Like Tyrosine Kinase 3