Identification of a novel e8/a4 BCR/ABL fusion transcript in a case of a transformed Sézary syndrome

Evelyne Callet-Bauchu; Gilles Salles; Sophie Gazzo; Stéphane Dalle; Françoise Berger; Sandrine Hayette

doi:10.3324/haematol.11341

Identification of a novel e8/a4 BCR/ABL fusion transcript in a case of a transformed Sézary syndrome

Haematologica. 2007 Sep;92(9):1277-8. doi: 10.3324/haematol.11341.

Authors

Evelyne Callet-Bauchu, Gilles Salles, Sophie Gazzo, Stéphane Dalle, Françoise Berger, Sandrine Hayette

PMID: 17768128
DOI: 10.3324/haematol.11341

Abstract

This report deals with a case of Sézary syndrome, a rare peripheral T-cell lymphoproliferative disorder, in which cytogenetic analysis performed during the disease transformation revealed the presence of a t(9;22) (q34;q11.2) translocation. Molecular analyses identified a new transcript, an e8a4 BCR-ABL fusion mRNA which could be responsible for the disease transformation.

Publication types

Case Reports
Letter
Research Support, Non-U.S. Gov't

MeSH terms

Aged
Chromosomes, Human, Pair 22 / genetics
Chromosomes, Human, Pair 9 / genetics
Fatal Outcome
Female
Fusion Proteins, bcr-abl / genetics*
Humans
In Situ Hybridization, Fluorescence
Karyotyping
Sezary Syndrome / diagnosis
Sezary Syndrome / drug therapy
Sezary Syndrome / genetics*
Translocation, Genetic

Substances

Fusion Proteins, bcr-abl