Abstract
A series of 92 Chinese children newly diagnosed with acute lymphoblastic leukemia (ALL) were examined for the ETV6-RUNX1 (previously TEL-AML1) fusion gene by using a nested reverse transcriptase-polymerase chain reaction. ETV6-RUNX1 fusion transcripts were detected in 21 of 92 patients (22.8%): 16 with common ALL, 4 with precursor B-cell ALL, and 1 with T-ALL. The prevalence of ETV6-RUNX1 positivity was 24.7% (20/81) in childhood B-lineage ALL. The prevalence of ETV6-RUNX1 in Chinese pediatric ALL patients proved to be similar to that found in other countries.
MeSH terms
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Child
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Child, Preschool
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China
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Core Binding Factor Alpha 2 Subunit / biosynthesis*
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Core Binding Factor Alpha 2 Subunit / genetics*
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ETS Translocation Variant 6 Protein
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Female
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Gene Rearrangement
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Humans
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Immunophenotyping
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Infant
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Infant, Newborn
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Male
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Models, Genetic
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Oncogene Proteins, Fusion / genetics*
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / ethnology
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics*
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / metabolism
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Proto-Oncogene Proteins c-ets / biosynthesis*
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Proto-Oncogene Proteins c-ets / genetics*
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Repressor Proteins / biosynthesis*
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Repressor Proteins / genetics*
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Reverse Transcriptase Polymerase Chain Reaction
Substances
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Core Binding Factor Alpha 2 Subunit
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Oncogene Proteins, Fusion
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Proto-Oncogene Proteins c-ets
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RUNX1 protein, human
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Repressor Proteins