PPARgamma gene C161T substitution is associated with reduced risk of coronary artery disease and decreased proinflammatory cytokine expression

Am Heart J. 2007 Oct;154(4):718-24. doi: 10.1016/j.ahj.2007.06.009. Epub 2007 Aug 27.

Abstract

Background: Peroxisome proliferator-activated receptor gamma (PPARgamma) is a transcription factor implicated in the expression of proinflammatory cytokines in atheroma-associated cells, and the expression of proinflammatory cytokines, such as tumor necrosis factor alpha (TNF-alpha) and matrix metalloproteinases (MMPs), represents a critical step in atherogenesis and atherosclerosis. In this study, we test the hypothesis of whether a polymorphism corresponding to C161T substitution in exon 6 of the PPARgamma gene may affect the expression of proinflammatory cytokines and the onset of coronary artery diseases (CADs) in a Chinese population.

Methods: We have studied distribution of the PPARgamma C161T substitution at exon 6 in 247 patients with CAD and 214 patients with chest pain syndrome. The plasma concentrations of MMP-9 and TNF-alpha were measured by enzyme-linked immunosorbent assay.

Results: The results showed that the frequencies of the CC, CT, and TT genotypes were 61.9%, 34.0%, and 4.1% in CAD, and 51.4%, 45.3%, and 3.3% in chest pain syndrome, respectively. There was a significant association between the PPARgamma C161T polymorphism and CAD. The T allele carriers (CT + TT) had significantly reduced CAD risk compared with the CC homozygotes (odds ratio 0.547, 95% CI 0.327-0.831, P = .012) in a logistic regression model after controlling known independent factors for CAD. The CC homozygotes also had increased MMP-9 and TNF-alpha levels compared with T allele carriers. Moreover, the CC homozygotes were more susceptible to acute coronary syndrome than T allele carriers.

Conclusions: PPARgamma C161T polymorphism was associated with angiographically documented CAD in a Chinese population. The T allele of the PPARgamma gene might have a protective effect on the progression of CAD and reduce the onset of acute coronary syndrome, which might be associated with the decreased expression of MMP-9 and TNF-alpha in patients with CAD.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Angina Pectoris, Variant / blood
  • Angina Pectoris, Variant / genetics
  • Asian People / genetics
  • Chest Pain / genetics
  • Coronary Disease / genetics*
  • Disease Progression
  • Female
  • Genotype
  • Humans
  • Logistic Models
  • Male
  • Matrix Metalloproteinase 9 / blood*
  • Middle Aged
  • Myocardial Infarction / blood
  • Myocardial Infarction / genetics
  • PPAR gamma / genetics*
  • Polymorphism, Genetic / physiology*
  • Polymorphism, Restriction Fragment Length
  • Risk Assessment
  • Syndrome
  • Tumor Necrosis Factor-alpha / blood*

Substances

  • PPAR gamma
  • Tumor Necrosis Factor-alpha
  • Matrix Metalloproteinase 9