Objective: To determine whether genetic variability in the intron 1 region of the gamma 2 actin gene (enteric type) contributes to the development of obstetric complications.
Study design: The study involved 57 obstetric cholestasis and 133 preeclampsia patients and a control group of 115 healthy women in whom polymerase chain reaction detection of insertion-deletion polymorphism in the gamma 2 actin gene was investigated. Chi(2) analysis was used to assess genotype and allele frequency differences between the study groups.
Results: The distribution of I and D alleles was equal in obstetric cholestasis (p = 0.652), preeclampsia (p = 0.609) and control groups. None of the gamma 2 actin gene genotypes were significantly overrepresented in obstetric cholestasis (p = 0.540) or preeclampsia (p = 0.680) groups compared to the control group.
Conclusion: This insertion-deletion polymorphism in the intron 1 of the gamma 2 actin gene is unlikely to play any significant role in obstetric cholestasis or preeclampsia in patients from eastern Finland.
(c) 2007 S. Karger AG, Basel