Abstract
We analyzed IS6110-associated polymorphisms in the phospholipase C genes of 107 isolates of Mycobacterium tuberculosis selected to be representative of isolates circulating in central Russia. We found that the majority of Latin American-Mediterranean family strains contained an insertion in a unique position in the plcA gene, suggesting a common ancestor. This insertion can serve as a specific genetic marker for this group, which we designate the LAM-RUS family.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Bacterial Proteins
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Cluster Analysis
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DNA Transposable Elements / genetics
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DNA, Bacterial / genetics
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Humans
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Mycobacterium tuberculosis / classification*
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Mycobacterium tuberculosis / genetics*
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Mycobacterium tuberculosis / isolation & purification
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Phylogeny
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Polymorphism, Genetic*
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Russia / epidemiology
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Sequence Homology
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Tuberculosis / epidemiology
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Tuberculosis / microbiology*
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Type C Phospholipases
Substances
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Bacterial Proteins
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DNA Transposable Elements
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DNA, Bacterial
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Type C Phospholipases
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MpcA protein, Mycobacterium tuberculosis