Abstract
Huntington disease is caused by polyglutamine expansion in huntingtin, a 350 kD protein that is ubiquitously expressed and widely distributed at the subcellular level. Recently, Kaltenbach et al. identified a large collection of novel huntingtin-interacting proteins, several of which modify mutant huntingtin toxicity in Drosophila. Thus, the interaction of mutant huntingtin with certain protein partners can influence its toxicity and therefore the severity and/or progression of Huntington disease.
Publication types
-
Research Support, N.I.H., Extramural
MeSH terms
-
Animals
-
DNA-Binding Proteins / genetics
-
DNA-Binding Proteins / metabolism
-
Drosophila melanogaster / metabolism
-
Humans
-
Huntingtin Protein
-
Huntington Disease / genetics*
-
Huntington Disease / metabolism*
-
Nerve Tissue Proteins / genetics*
-
Nerve Tissue Proteins / metabolism*
-
Nuclear Proteins / genetics*
-
Nuclear Proteins / metabolism*
-
Peptides / metabolism
-
Two-Hybrid System Techniques
Substances
-
DNA-Binding Proteins
-
HIP1 protein, human
-
HTT protein, human
-
Huntingtin Protein
-
Nerve Tissue Proteins
-
Nuclear Proteins
-
Peptides
-
polyglutamine