Abstract
We investigated the genotypes of methylenetetrahydrofolate reductase (MTHFR) and reduced folate carrier-1 (RFC-1), and the serum concentrations of methotrexate (MTX) in 100 outpatients with rheumatoid arthritis (RA). Frequencies of MTHFR C677T and A1298C were similar to those reported in Japanese RA patients, while frequencies of RFC-1 G80A genotypes differed from those reported in RA patients in the United States. No correlations were found between these genotypes and serum MTX levels.
MeSH terms
-
Antirheumatic Agents / blood*
-
Antirheumatic Agents / pharmacokinetics
-
Antirheumatic Agents / therapeutic use
-
Arthritis, Rheumatoid / drug therapy*
-
Arthritis, Rheumatoid / enzymology
-
Arthritis, Rheumatoid / genetics
-
Chi-Square Distribution
-
Female
-
Gene Frequency
-
Genotype
-
Humans
-
Male
-
Membrane Transport Proteins / genetics*
-
Methotrexate / blood*
-
Methotrexate / pharmacokinetics
-
Methotrexate / therapeutic use
-
Methylenetetrahydrofolate Reductase (NADPH2) / genetics*
-
Middle Aged
Substances
-
Antirheumatic Agents
-
Membrane Transport Proteins
-
SLC19A2 protein, human
-
Methylenetetrahydrofolate Reductase (NADPH2)
-
Methotrexate