Modulation of type 1 diabetes susceptibility by tumor necrosis factor alpha -308 G/A and lymphotoxin alpha +249 A/G haplotypes and lack of linkage disequilibrium with predisposing DQB1-DRB1 haplotypes in Bahraini patients

Clin Vaccine Immunol. 2008 Feb;15(2):379-81. doi: 10.1128/CVI.00410-07. Epub 2007 Nov 7.

Abstract

Tumor necrosis factor alpha (TNF-alpha) -308 G/A and lymphotoxin alpha (LTalpha) +249 A/G single-nucleotide polymorphisms were investigated in 228 type 1 diabetes mellitus (T1DM) patients and 240 controls. Only LTalpha +249G allele and +249G/+249G genotype frequencies were higher among patients, and no linkage disequilibrium was found between TNF-alpha/LTalpha alleles and susceptible/protective DRB1-DQB1 haplotypes. TNF-alpha/LTalpha T1DM-susceptible (-308G/+249G) and protective (-308G/+249A) haplotypes were identified.

MeSH terms

  • Adolescent
  • Adult
  • Bahrain
  • Child
  • Child, Preschool
  • Diabetes Mellitus, Type 1 / genetics*
  • Female
  • Gene Frequency
  • Genetic Predisposition to Disease*
  • Genotype
  • HLA-DQ Antigens / genetics*
  • HLA-DQ beta-Chains
  • Haplotypes
  • Humans
  • Linkage Disequilibrium*
  • Lymphotoxin-alpha / genetics*
  • Male
  • Polymorphism, Genetic
  • Tumor Necrosis Factor-alpha / genetics*

Substances

  • HLA-DQ Antigens
  • HLA-DQ beta-Chains
  • HLA-DQbeta antigen
  • Lymphotoxin-alpha
  • Tumor Necrosis Factor-alpha