Analysis of associations of NAT2 gene polymorphisms with the risk of lung cancer

M V Nikishina; V A Vavilin; S I Makarova; V V Lyakhovich

doi:10.1007/s10517-007-0023-0

Analysis of associations of NAT2 gene polymorphisms with the risk of lung cancer

Bull Exp Biol Med. 2007 Jan;143(1):83-6. doi: 10.1007/s10517-007-0023-0.

Authors

M V Nikishina¹, V A Vavilin, S I Makarova, V V Lyakhovich

Affiliation

¹ Institute of Molecular Biology and Biophysics, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk. mnikishina@rambler.ru

PMID: 18019020
DOI: 10.1007/s10517-007-0023-0

Abstract

The incidence of 5 polymorphisms of N-acetyltransferase-2 gene was evaluated in patients with lung cancer. A803G polymorphism is a factor of lung cancer resistance in tobacco smoking Caucasians in Novosibirsk. Opposite effects of NAT2 gene polymorphisms on the risk of lung cancer are possible.

MeSH terms

Arylamine N-Acetyltransferase / genetics*
Case-Control Studies
Female
Genetic Predisposition to Disease
Humans
Lung Neoplasms / etiology
Lung Neoplasms / genetics*
Lung Neoplasms / metabolism
Male
Middle Aged
Polymorphism, Genetic
Risk
Siberia
Smoking / adverse effects
Smoking / genetics
Smoking / metabolism
White People

Substances

Arylamine N-Acetyltransferase
NAT2 protein, human