Abstract
Genetic and acquired abnormalities in complement factor H (CFH) have been associated with two different human renal diseases: haemolytic uraemic syndrome and membrano proliferative glomerulonephritis. The new genetic and pathogenetic findings in these diseases and their clinical implications for the management and cure of patients are reviewed in this paper.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Complement Factor H / genetics
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Glomerulonephritis, Membranoproliferative / genetics*
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Glomerulonephritis, Membranoproliferative / immunology
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Glomerulonephritis, Membranoproliferative / therapy
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Hemolytic-Uremic Syndrome / genetics*
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Hemolytic-Uremic Syndrome / immunology
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Hemolytic-Uremic Syndrome / therapy
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Humans
Substances
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CFH protein, human
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Complement Factor H