Abstract
Myelodysplastic syndromes (MDS) in childhood are rare hematologic diseases. MDS with t(3;5) (NPM/MLF1) is an unusual subtype without a well-defined clinical and prognostic pattern. A poor outcome has been reported, suggesting that hematopoietic transplantation is the only treatment option. Here in we described a 2-year-old child diagnosed with the disease, without a suitable hematopoietic donor, treated early in the disease with chemotherapy. He is alive and well 4 years after the end of treatment. This unusual MDS needs further studies to better understand the disease.
MeSH terms
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Antigens, CD / blood
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Child, Preschool
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Chromosomes, Human, Pair 3*
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Chromosomes, Human, Pair 5*
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Cyclophosphamide / therapeutic use
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Cytarabine / therapeutic use
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Doxorubicin / therapeutic use
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Humans
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Leukemia, Myeloid, Acute / drug therapy
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Leukemia, Myeloid, Acute / genetics*
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Leukemia, Myeloid, Acute / immunology
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Male
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Methotrexate / therapeutic use
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Oncogene Proteins, Fusion / genetics*
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Prednisone / therapeutic use
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Thioguanine / therapeutic use
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Translocation, Genetic*
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Treatment Outcome
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Vincristine / therapeutic use
Substances
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Antigens, CD
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NPM-MLF1 protein, human
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Oncogene Proteins, Fusion
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Cytarabine
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Vincristine
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Doxorubicin
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Cyclophosphamide
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Thioguanine
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Prednisone
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Methotrexate