Abstract
We genotyped three polymorphisms of the promoter region of the interleukin-10 (IL-10) gene in 220 CF patients from the CF Center of Bari, and tested for an association between genetic variants of the cytokine and chronic airway colonization with Pseudomonas aeruginosa. We found that carriers of the high-IL-10-producing-GCC haplotype had significantly higher risk of chronic pulmonary infection with the pathogen.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Adolescent
-
Adult
-
Child
-
Child, Preschool
-
Cohort Studies
-
Cystic Fibrosis / genetics*
-
Cystic Fibrosis / immunology*
-
Cystic Fibrosis / microbiology
-
Female
-
Genetic Predisposition to Disease / genetics
-
Haplotypes / genetics
-
Humans
-
Interleukin-10 / genetics*
-
Male
-
Middle Aged
-
Polymorphism, Single Nucleotide / genetics*
-
Promoter Regions, Genetic / genetics
-
Pseudomonas Infections / genetics
-
Pseudomonas Infections / immunology
-
Pseudomonas aeruginosa / immunology
-
Pseudomonas aeruginosa / isolation & purification*
-
Young Adult