Breast cancer risk and the BRCA1 interacting protein CTIP

Kylie L Gorringe; David Y H Choong; Geoffrey J Lindeman; Jane E Visvader; Ian G Campbell

doi:10.1007/s10549-007-9862-7

Breast cancer risk and the BRCA1 interacting protein CTIP

Breast Cancer Res Treat. 2008 Nov;112(2):351-2. doi: 10.1007/s10549-007-9862-7. Epub 2007 Dec 20.

Authors

Kylie L Gorringe¹, David Y H Choong, Geoffrey J Lindeman, Jane E Visvader, Ian G Campbell

Affiliation

¹ VBCRC Cancer Research Laboratory, Peter MacCallum Cancer Centre, East Melbourne, VIC, Australia.

PMID: 18095152
DOI: 10.1007/s10549-007-9862-7

Abstract

Mutations in BRCA1 predispose to breast cancer. CTIP interacts with BRCA1 and so could also be associated with increased risk. We screened CTIP for germline mutations in 210 probands of breast cancer families including 129 families with no mutations in BRCA1 or BRCA2. No coding variants were detected in CTIP, therefore, it is unlikely to be involved in breast cancer risk.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Australia
BRCA1 Protein / genetics*
BRCA1 Protein / physiology*
Breast Neoplasms / ethnology
Breast Neoplasms / genetics*
Breast Neoplasms / metabolism*
Carrier Proteins / genetics*
Carrier Proteins / physiology*
DNA Mutational Analysis
Endodeoxyribonucleases
Family Health
Female
Genes, BRCA1*
Genetic Predisposition to Disease
Humans
Male
Mass Screening / methods
Microsatellite Repeats
Mutation*
Nuclear Proteins / genetics*
Nuclear Proteins / physiology*
Risk

Substances

BRCA1 Protein
BRCA1 protein, human
Carrier Proteins
Nuclear Proteins
Endodeoxyribonucleases
RBBP8 protein, human