Abstract
IL-17-producing CD4(+) T cells, so called T(h)17 cells, constitute a newly identified inflammatogenic cell population, which is critically involved in some inflammatory diseases. To explore the role of T(h)17 cells in murine experimental autoimmune uveoretinitis (EAU), a model of human autoimmune uveitis where T(h)1 responses predominantly participate in the pathogenesis, IL-17(-/-) mice were immunized with interphotoreceptor retinoid-binding protein peptide 1-20 for disease induction. Funduscopic examination revealed that EAU was induced in IL-17(-/-) mice just like in wild-type (WT) mice at early phases of the disease. However, at later/maintenance phases, the severity was significantly reduced in IL-17(-/-) mice. Expression of IFN-gamma and MCP-1 was comparable between WT and IL-17(-/-) mice during the time course. In vivo blockade of IFN-gamma and IL-4 resulted in exacerbation of EAU at later phases with augmented IL-17 production. Taken together, our data demonstrated that IL-17/T(h)17 participates in the late phases of EAU and also that T(h)1 and T(h)17 responses are differentially required for EAU.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Animals
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Autoimmune Diseases* / chemically induced
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Autoimmune Diseases* / immunology
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Autoimmune Diseases* / physiopathology
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CD4-Positive T-Lymphocytes / immunology
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CD4-Positive T-Lymphocytes / metabolism
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Cytokines / metabolism
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Eye Proteins / administration & dosage
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Eye Proteins / chemistry
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Eye Proteins / toxicity
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Humans
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Inflammation / immunology
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Inflammation / physiopathology
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Interferon-gamma / genetics
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Interferon-gamma / immunology
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Interferon-gamma / metabolism*
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Interleukin-17 / genetics
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Interleukin-17 / immunology
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Interleukin-17 / metabolism*
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Mice
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Mice, Inbred C57BL
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Mice, Knockout
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Molecular Sequence Data
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Retinitis* / chemically induced
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Retinitis* / immunology
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Retinitis* / physiopathology
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Retinol-Binding Proteins / administration & dosage
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Retinol-Binding Proteins / chemistry
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Retinol-Binding Proteins / toxicity
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Th1 Cells
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Uveitis* / chemically induced
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Uveitis* / immunology
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Uveitis* / physiopathology
Substances
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Cytokines
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Eye Proteins
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Interleukin-17
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Retinol-Binding Proteins
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interstitial retinol-binding protein
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Interferon-gamma