A dead end for microRNAs

Cell. 2007 Dec 28;131(7):1226-7. doi: 10.1016/j.cell.2007.12.004.

Abstract

Dead end (Dnd1) is an RNA-binding protein that mediates germ-cell viability and suppresses the formation of germ-cell tumors. Kedde et al. (2007) now provide evidence that Dnd1 mediates these effects by counteracting microRNA-mediated silencing of mRNAs.

Publication types

  • Comment

MeSH terms

  • 3' Untranslated Regions
  • Animals
  • Binding Sites
  • Cell Survival / genetics
  • Cell Transformation, Neoplastic / genetics
  • Cell Transformation, Neoplastic / metabolism
  • Connexin 43 / genetics
  • Connexin 43 / metabolism
  • Cyclin-Dependent Kinase Inhibitor p27 / genetics
  • Cyclin-Dependent Kinase Inhibitor p27 / metabolism
  • Gene Expression Regulation, Developmental*
  • Gene Silencing*
  • Germ Cells / metabolism*
  • Humans
  • MicroRNAs / metabolism*
  • Mutation
  • Protein Binding
  • Protein Serine-Threonine Kinases / genetics
  • Protein Serine-Threonine Kinases / metabolism
  • RNA, Messenger / metabolism*
  • RNA-Binding Proteins / genetics
  • RNA-Binding Proteins / metabolism*
  • Regulatory Sequences, Ribonucleic Acid
  • Transcription, Genetic*
  • Zebrafish
  • Zebrafish Proteins / genetics
  • Zebrafish Proteins / metabolism*

Substances

  • 3' Untranslated Regions
  • Connexin 43
  • MicroRNAs
  • RNA, Messenger
  • RNA-Binding Proteins
  • Regulatory Sequences, Ribonucleic Acid
  • Zebrafish Proteins
  • nanos3 protein, zebrafish
  • Cyclin-Dependent Kinase Inhibitor p27
  • Protein Serine-Threonine Kinases