Abstract
Dead end (Dnd1) is an RNA-binding protein that mediates germ-cell viability and suppresses the formation of germ-cell tumors. Kedde et al. (2007) now provide evidence that Dnd1 mediates these effects by counteracting microRNA-mediated silencing of mRNAs.
MeSH terms
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3' Untranslated Regions
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Animals
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Binding Sites
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Cell Survival / genetics
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Cell Transformation, Neoplastic / genetics
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Cell Transformation, Neoplastic / metabolism
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Connexin 43 / genetics
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Connexin 43 / metabolism
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Cyclin-Dependent Kinase Inhibitor p27 / genetics
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Cyclin-Dependent Kinase Inhibitor p27 / metabolism
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Gene Expression Regulation, Developmental*
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Gene Silencing*
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Germ Cells / metabolism*
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Humans
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MicroRNAs / metabolism*
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Mutation
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Protein Binding
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Protein Serine-Threonine Kinases / genetics
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Protein Serine-Threonine Kinases / metabolism
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RNA, Messenger / metabolism*
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RNA-Binding Proteins / genetics
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RNA-Binding Proteins / metabolism*
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Regulatory Sequences, Ribonucleic Acid
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Transcription, Genetic*
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Zebrafish
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Zebrafish Proteins / genetics
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Zebrafish Proteins / metabolism*
Substances
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3' Untranslated Regions
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Connexin 43
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MicroRNAs
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RNA, Messenger
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RNA-Binding Proteins
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Regulatory Sequences, Ribonucleic Acid
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Zebrafish Proteins
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nanos3 protein, zebrafish
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Cyclin-Dependent Kinase Inhibitor p27
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Protein Serine-Threonine Kinases