Abstract
To investigate the influence of glutathione S-transferase T1 (GSTT1) gene polymorphism on Chinese infertile patients with varicocele, 63 infertile patients with varicocele and 54 healthy fertile controls were recruited in this case-control study. Our results show that oxidative damage may be the cause of infertility in patients with varicocele, and GSTT1 null genotype predisposes to over oxidative damage to spermatocytes of infertile patients with varicocele.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antioxidants / analysis
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Asian People / genetics*
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Biomarkers / analysis
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Case-Control Studies
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DNA Damage
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DNA, Mitochondrial / analysis
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Gene Deletion
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Genetic Predisposition to Disease
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Glutathione Transferase / genetics*
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Humans
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Infertility, Male / enzymology
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Infertility, Male / ethnology
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Infertility, Male / genetics*
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Male
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Malondialdehyde / analysis
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Nitric Oxide / analysis
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Odds Ratio
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Oxidative Stress / genetics
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Phenotype
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Polymorphism, Genetic*
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Risk Assessment
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Semen / chemistry
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Varicocele / complications
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Varicocele / enzymology
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Varicocele / ethnology
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Varicocele / genetics*
Substances
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Antioxidants
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Biomarkers
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DNA, Mitochondrial
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Nitric Oxide
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Malondialdehyde
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glutathione S-transferase T1
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Glutathione Transferase