Association between a G894T polymorphism of eNOS gene and essential hypertension in Hani and Yi minority groups of China

Arch Med Res. 2008 Feb;39(2):222-5. doi: 10.1016/j.arcmed.2007.08.002. Epub 2007 Nov 19.

Abstract

Background: Endothelial nitric oxide synthase (eNOS) plays an important role in maintaining blood pressure homeostasis and vascular integrity. Recently, a G894T polymorphism in exon 7 of the eNOS gene has been reported to be associated with high blood pressure. We investigated the association between this polymorphism and essential hypertension (EH) in Hani (n=305 individuals) and Yi (n=233 individuals) minorities of China.

Methods: eNOS genotyping with polymerase chain reaction-restriction fragment length polymorphism was performed in 267 normotensive (NT) subjects and 271 EH subjects.

Results: The frequencies of eNOS G894T genotypes in NT controls and EH cohort in Hani population were GG: 0.714 vs. 0.581; GT+TT: 0.286 vs. 0.419, respectively. The frequencies of eNOS G894T genotypes in NT controls and EH cohort in Yi population were GG: 0.552 vs. 0.717; GT+TT: 0.448 vs. 0.283, respectively. There was a significant difference in G894T genotype distribution between NTs and hypertensives in both Hani and Yi populations (p<0.05).

Conclusions: The present study suggested an association between a G894T polymorphism of eNOS gene and EH in Hani and Yi minority groups of China.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Asian People
  • Carrier Proteins / genetics*
  • Case-Control Studies
  • China
  • Female
  • Genotype
  • Humans
  • Hypertension / enzymology
  • Hypertension / epidemiology
  • Hypertension / genetics*
  • Male
  • Middle Aged
  • Polymerase Chain Reaction
  • Polymorphism, Single Nucleotide*
  • Ubiquitin-Protein Ligases

Substances

  • Carrier Proteins
  • NOSIP protein, human
  • Ubiquitin-Protein Ligases